Fifth Avenue is a major thoroughfare in the center of the borough of Manhattan in New York City. It runs through the heart of Midtown and along the eastern side of Central Park, and because of the expensive park-view real estate and historical mansions along its course, it is a symbol of wealthy New York. Between Thirty-fourth Street and Fifty-ninth Street it is also one of the premier shopping streets in the world, often paired with Oxford Street in London and the Champs Elysées in Paris. It is one of the most expensive streets in the world, on a par with Paris, London, and Tokyo lease prices: the "most expensive street in the world" moniker changes depending on currency fluctuations and local economic conditions from year to year.

The avenues run north-south and Fifth Avenue is the dividing line for the streets in Manhattan,

which run east-west. For instance it separates East Fifty-ninth Street from West Fifty-ninth Street. As the zero-numbering point for its street addresses, numbers increase in both directions as one moves away from Fifth Avenue, with 1 East Fifty-ninth Street on the corner at Fifth Avenue, and 300 East Fifty-ninth Street located three blocks to the east of it.
Fifth Avenue extends northward from the northern edge of Washington Square Park through Greenwich Village, Midtown, and the Upper East Side.

Fifth Avenue

Fifth Avenue Sign

The Guggenheim Museum at Eighty-ninth Street

Fifth Avenue, which had two-way traffic over most of its course until the early 1960s, now allows two-way traffic north of 135th Street only. South of 135th Street, Fifth Avenue allows one-way southbound traffic only while northbound traffic may take Madison Avenue. From 124th Street to 120th Street, Fifth Avenue is cut off by Marcus Garvey Park, with southbound traffic diverted around the park via Mount Morris Park West.

Reference: www.wikipedia.com